Neal Stephenson's new novel Quicksilver will be released in September. The book is set during the 1600s and includes both fictional characters and historical figures such as Isaac Newton. It is the first of three books in Stephenson's Baroque Cycle. The other two novels are scheduled to follow Quicksilver at 6-month intervals. Stephenson discusses his new book and other things in this Wired interview.
This article by Timothy Ferris discusses the life of Isaac Newton.